Members of Dryden Ontario Provincial Police responded to a collision involving two tractor trailers on Sunday morning.
It happened west of Dryden, police arriving to find that a vehicle heading east collided with another that was parked on the shoulder of the eastbound lane.
The driver of the eastbound tractor trailer, 31-year-old Alexie Plevak of Woodstock, was pronounced dead at the scene.
The passenger and driver of the parked vehicle did not suffer any injures.
Highway 17 was closed from Dryden to Vermillion Bay for around nine hours while OPP investigated.
The Machin Volunteer Fire Department and Northwest Emergency Medical Services (EMS) also responded to this call.