Three from Southern Ontario have a future date with a judge.
They are alleged to be connected to drug-trafficking activity as officers raided the home on Picton Avenue near Blucher Avenue and Walkover Street.
Thunder Bay Police were called out just before 12:30 a.m. on Monday to investigate reports of a disturbance.
Suspected cocaine, suspected heroin, and cash were collected.
A 15-year-old and a 16-year-old were among the arrested with their identities being withheld in accordance with the Youth Criminal Justice Act.